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Question of the Day

A 14-year-old male, currently receiving systemic corticosteroid therapy, presents to the emergency department with an acute onset of severe pain and swelling in his right knee joint. On examination, the knee is erythematous, warm, exquisitely tender, and range of motion is severely restricted. Which of the following is the most probable diagnosis?
Answer Details
Correct Answer: C. Septic arthritis, requiring urgent joint aspiration and broad-spectrum intravenous antibiotics due to the high risk of joint destruction and systemic sepsis.
📝 Explanation:

Given the patient's age, immunosuppressed state due to corticosteroid therapy, and acute monoarticular presentation with signs of inflammation, septic arthritis is the most critical and probable diagnosis. This condition necessitates immediate investigation and treatment to prevent irreversible joint damage and systemic complications, aligning with the urgent management protocols outlined in the Paediatric STGs and EML 2023 Edition for septic arthritis.

🔤 Memory spark:

SEPTIC: Steroids Equal Pyogenic Trouble In Children

Why Wrong:
A    Acute Gouty Arthritis: While possible, gout is exceedingly rare in a 14-year-old without a strong family history or specific metabolic enzyme deficiencies (e.g., Lesch-Nyhan syndrome) leading to severe hyperuricemia. It typically affects older adults and often presents in the first metatarsophalangeal joint. The patient's steroid use does not directly predispose to gout in this context.
B    Pseudogout (Calcium Pyrophosphate Deposition Disease - CPPD): This condition is primarily a disease of older adults, typically presenting in individuals over 60 years of age. It is characterized by the deposition of calcium pyrophosphate crystals in joints, often visible as chondrocalcinosis on radiographs. It is highly improbable in a 14-year-old.
D    Acute Rheumatic Fever (ARF): ARF typically presents as a migratory polyarthritis, affecting multiple large joints sequentially, rather than a single joint with severe local inflammation. It is a sequela of Group A Streptococcal pharyngitis and is associated with other major criteria (carditis, chorea, erythema marginatum, subcutaneous nodules) and minor criteria. While a painful knee can be part of ARF, the acute, severe, monoarticular presentation in an immunosuppressed patient makes septic arthritis a far more urgent and likely diagnosis.
🏥 Setting:

Emergency department

Urgency:

Critical

🎯 Learning Objective:

Recognize septic arthritis as a medical emergency in immunocompromised patients and initiate appropriate urgent management.

🗝️ Key Teaching:

Immunosuppression significantly increases infection risk; septic arthritis requires urgent diagnosis and treatment; joint aspiration and blood cultures are essential for definitive management.

💎 Clinical Pearls:

In immunosuppressed patients, always consider septic arthritis first for acute monoarthritis - it's a medical emergency with potential for rapid joint destruction and systemic sepsis. Do not delay aspiration and empiric antibiotics.

📖 Reference:

Paediatric STGs and EML 2023 Edition, Arthritis septic

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